25-Methoxyhispidol A, a novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR/c-Src signaling pathway in MDA-MB-231 human breast cancer cells

► Anti-proliferative activity of 25-methoxyhispidol A (25-MHA) in MDA-MB-231 cells. ► 25-MHA induces G0/G1 phase cell cycle arrest. ► 25-MHA downregulates cyclin D1, CDK4/CDK2, cyclin A, and upregulates p21. ► 25-MHA modulates EGFR/c-Src/mTOR signaling pathways.