کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5853998 | 1130871 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We isolated anthocyanins from fruits of Vitis coignetiae Pulliat, characterized the anthocyanin profile, and investigated the anti-invasive effects of the anthocyanins on human colon cancer cells. The anthocyanins inhibited cell invasion in a dose-dependent manner, as measured by Matrigel invasion assays, by suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression. The anti-invasive activity of the anthocyanins was associated with modulation of constitutive nuclear factor κB (NF-κB) activation. The activation of NF-κB triggered by tumor necrosis factor-α was also inhibited by the anthocyanins through suppression IκBα phosphorylation. AIMs inhibited the expression of NF-κB-regulated proteins. In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-κB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-κB activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 3, March 2010, Pages 903-909
Journal: Food and Chemical Toxicology - Volume 48, Issue 3, March 2010, Pages 903-909
نویسندگان
Jeong Won Yun, Won Sup Lee, Min Jeong Kim, Jing Nan Lu, Myung Hee Kang, Hoon Gu Kim, Dong Chul Kim, Eun Ju Choi, Jin Young Choi, Hae Gyeong Kim, Yun-Kyoung Lee, Chung Ho Ryu, GonSup Kim, Yung Hyun Choi, Ock Jin Park, Sung Chul Shin,