Rhein protects against acetaminophen-induced hepatic and renal toxicity

► The protective effects of rhein on Acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats were investigated in this study. ► The histopathological damage of liver and kidney could be significantly ameliorated by rhein treatment. ► The protective effects of rhein against liver and kidney injuries might result from the amelioration of APAP-induced oxidative stress.