کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854353 | 1130901 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of acute alcohol consumption and vitamin E co-treatment on oxidative stress parameters in rats tongue
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کلمات کلیدی
LSDTBARSDNPHCATROS - ROSα-Tocopherol - α-توکوفرولEthanol - اتانولOxidative stress - تنش اکسیداتیوleast significant difference - حداقل تفاوت قابل توجهیdinitrophenylhydrazine - دینیتروفنیل هیدرازینFree radicals - رادیکال آزادSOD - سدSuperoxide dismutase activity - فعالیت سوپر اکسید دیسموتازCatalase activity - فعالیت کاتالازOral mucosa - مخاط دهانReactive oxygen substances - مواد اکسیژن واکنشیthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to evaluate the effects of acute alcohol consumption and vitamin E co-treatment upon oxidative stress parameters in rats tongue. Thirty-eight, Wistar rats were separated into five groups (alcohol, alcohol/vitamin E, control, Tween, vitamin E). Alcohol and alcohol vitamin E groups had the standard diet, and 40% alcohol on drinking water. Other groups were fed with the same standard diet and water ad libitum. Vitamin E was given by gavage to vitamin E and alcohol/vitamin E rats twice a week. Alcohol and control groups were subjected to saline gavage and Tween group to 5% Tween 80 solution, the vitamin E vehicle. At day 14, the animals were anesthetized and specimens were obtained from tongue. Lipid peroxidation (TBARS), protein oxidative damage, catalase (CAT) and superoxide dismutase (SOD) activities were quantified. Alcohol group decreased TBARS in relation to control group and alcohol vitamin-treated animals decreased TBARS when compared to Tween and vitamin E groups. SOD activity was lower and CAT activity was higher in animals treated with both alcohol and vitamin E. These results suggest that short-term alcohol consumption decreases lipid peroxidation levels. Alternatively, alcohol/vitamin E group increased CAT, showing the toxicity of this association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1058-1063
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1058-1063
نویسندگان
V.C. Carrard, A.S. Pires, M. Mendez, F. Mattos, J.C.F. Moreira, M. Sant'Ana Filho,