Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit

► Despite a controlled agent, ketamine (KT) abuse is increasing in number. ► KT decreased Ca2+-activated K+ current (IK(Ca)) in hippocampal H19-7 cells with an IC50 value of 274 μM. ► In HEK293T cells expressing α-hslo, KT-induced decrease of IK(Ca) still existed. ► KT also increased electroporation-induced current in H19-7 cells.