Manganese mixture inhalation is a reliable Parkinson disease model in rats

► Manganese inhalation as a Parkinson disease model is progressive and bilateral which makes it more reliable. ► This model has only been characterized in mice. ► In order to have a well-supported and generalizable model in rodents, we used rats that inhaled a mixture of Manganese compounds. ► The mixture of Manganese compounds in rats caused motor alterations and 75.95% loss of dopaminergic neurons. ► The inhalation of the mixture of Mn compounds is a useful model in rodents for the study of PD.