Compound-specific effects of mutations at Val787 in DII-S6 of Nav1.4 sodium channels on the action of sodium channel inhibitor insecticides

► Mutations at V787 in rat Nav1.4 channels modulate slow inactivation gating. ► V787 mutations modulate SCI insecticide inhibition independent of changes in gating. ► Effects of V787 mutations on SCI insecticide inhibition are compound specific. ► Effects of V787 mutations on metaflumizone correlate with substituent hydrophobicity. ► V787 may be a unique determinant of metaflumizone binding.