Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

► In this study we determine the effect of Keap1 siRNA on the Nrf2-ARE pathway. ► Keap1 siRNA activated the Nrf2-ARE pathway and protected against oxidative stress. ► In vivo, Keap1 siRNA had modest protection in the MPTP model of Parkinson's disease. ► We conclude that Keap1 siRNA is a potential therapeutic for Parkinson's disease.