Toxicogenomic analysis of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells

Brominated flame retardants are suspected to act as disruptors of thyroid hormone signaling. This raises the concern that they might affect children's cognitive functions by influencing thyroid hormone signaling in the developing brain. We present here an in vitro analysis of the ability of the most common compounds, tetrabromobisphenol A (TBBPA) and BDE-209, to alter thyroid hormone response based on a model neural cell line and genome-wide analysis of gene expression.