Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: Involvement of glutamate excitotoxicity

- Roundup® induces Ca2+ influx through L-VDCC and NMDA receptor activation.
- The mechanisms underlying Roundup® neurotoxicity involve glutamatergic excitotoxicity.
- Kinase pathways participate in Roundup®-induced neural toxicity.
- Roundup® alters glutamate uptake, release and metabolism in hippocampal cells.