کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859264 | 1562337 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicological evaluation of 6:2 fluorotelomer alcohol
ترجمه فارسی عنوان
ارزیابی سمی 6: 2 الکل فلوراتومرور
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کلمات کلیدی
6: 2 الکل فلوراتومتر، 90 روزه موش دهان، سمیت ژنتیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
6:2 fluorotelomer alcohol (6:2 FTOH; CF3[CF2]5[CH2]2OH, CAS# 647-42-7) was evaluated for acute, genetic, and subchronic toxicity using in vitro and in vivo methods. In rats, 6:2 FTOH was considered to be slightly toxic by the oral (LD50Â =Â 1750Â mg/kg), and dermal (LD50Â >Â 5000Â mg/kg) routes. In rabbits, 6:2 FTOH was not a primary skin or eye irritant, and it did not produce a dermal sensitization response in mice. In a 90-day subchronic study, 6:2 FTOH was administered to rats by oral gavage (0, 5, 25, 125, 250Â mg/kg/day). Mortality was observed at 125 and 250Â mg/kg/day; deaths occurred after approximately three weeks of dosing and continued sporadically. The NOAEL in the subchronic study was 5Â mg/kg/day based on hematology and liver effects. 6:2 FTOH was not mutagenic in the bacterial reverse mutation test or in the mouse lymphoma assay and was not clastogenic in a chromosome aberration assay in human lymphocytes. The hazard classification for human health endpoints of 6:2 FTOH according to the United Nations Globally Harmonized System of Classification and Labeling of Chemicals (GHS) is Category 4 for acute oral toxicity based on an LD50 of 1750Â mg/kg. Other acute health endpoints including eye and skin irritation, skin sensitization, as well as genotoxicity, did not meet the criteria for hazard classification. Benchmark Dose Analysis was performed on the most sensitive endpoints from the 90-day oral gavage study and these levels were all above the study NOAEL of 5Â mg/kg/day. For risk assessment purposes, the recommended point of departure is the more conservative study NOAEL of 5Â mg/kg/day.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 319, 7 May 2014, Pages 1-9
Journal: Toxicology - Volume 319, 7 May 2014, Pages 1-9
نویسندگان
Tessa Serex, Satheesh Anand, Susan Munley, E. Maria Donner, Steven R. Frame, Robert C. Buck, Scott E. Loveless,