کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859436 | 1562348 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of exposure to amitraz on noradrenaline, serotonin and dopamine levels in brain regions of 30 and 60 days old male rats
ترجمه فارسی عنوان
اثر قرار گرفتن در معرض آمیتراز بر میزان نورآدرنالین، سروتونین و دوپامین در ناحیه مغز موشهای نر 30 روزه و 60 روزه
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کلمات کلیدی
DHMAVMADBH5-HTPL-TyrAAADDHPG5-hydroxytryptophandopamine-β-hydroxylaseCOMTl-3,4-dihydroxyphenylalanine - L-3،4-دی هیدروکسی فنیل آلانینl-DOPA - L-DOPAl-Tryptophan - l-تریپتوفانaldehyde dehydrogenase - آلدئید دهیدروژنازAldehyde reductase - آلدهید ردوکتازaromatic l-amino acid decarboxylase - آمونیوم اسید dearboxylaseVanillylmandelic acid - اسید وانیلیلیماندلیکAmitraz - امیرازtrh - بازارtyrosine hydroxylase - تیروزین هیدروکسیلازNeurotoxicology - عصب شناسیMale rats - موش صحرایی نرnormetanephrine - نورمنتانرینtryptophan hydroxylase - هیدروکسیلاز تریپتوفان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The effects of amitraz oral exposure (20, 50 and 80Â mg/kg bw, 5 days) on brain region monoamine levels of male rats at 30 and 60 days of age were examined. The amitraz-treated rats at the oral doses of 20 and 50Â mg/kg bw had no visible injury, i.e., any clinical signs of dysfunction observed in any of the animals. However, rats treated with amitraz at the highest dose (80Â mg/kg bw, 5 days) showed a slight motor incoordination after 1-2Â h of treatment. These signs were reversible approximately at 6Â h after dose. After the last dose of amitraz, NE, DA and 5-HT and its metabolites levels were determined in the brain regions hypothalamus, midbrain, prefrontal cortex, striatum and hippocampus by HPLC. Amitraz caused changes in the NE, DA and 5-HT and their metabolite levels in a brain regional-, dose- and age-related manner. In the brain regions studied, amitraz induced a statistically significant increase in 5-HT, NE and DA content with age interaction, but the NE increases in prefrontal cortex and hippocampus was without age interaction. Moreover, in the brain regions studied, amitraz induced a statistically significant decrease in the metabolite 5-HIAA, MHPG, DOPAC and HVA levels displaying an age interaction, excepting the 5-HIAA decrease in midbrain and the DOPAC decrease in hypothalamus and striatum which were without age interaction. Furthermore, amitraz evoked a statistically significant decrease in 5-HT, NE and DA turnover in the brain regions studied. The present findings indicate that amitraz significantly altered CNS monoaminergic neurotransmitters in a brain regional-, dose- and age-related manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 308, 7 June 2013, Pages 88-95
Journal: Toxicology - Volume 308, 7 June 2013, Pages 88-95
نویسندگان
J. Del Pino, M.A. MartÃnez, V. Castellano, E. Ramos, M.R. MartÃnez-Larrañaga, A. Anadón,