کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5859475 1562353 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line
چکیده انگلیسی

MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response to three triazole fungicides (myclobutanil, propiconazole, and triadimefon). The human hepatoma cell line (HepG2) was treated with the above triazoles for 3 h or 48 h. miRNA-based microarray experiments were carried out using the Agilent human miRNA v13 array. At early exposure (3 h), six miRNAs were differentially expressed and at late exposure (48 h), three miRNAs were significantly expressed. Overall, this study provides an array of potential biomarkers for the above triazole fungicides. Furthermore, these miRNAs induced by triazoles could be the foundation for the development of a miRNA-based toxic biomarker library that can predict environmental toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 303, 7 January 2013, Pages 94-98
نویسندگان
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