The 2,2′,4,4′-tetrabromodiphenyl ether hydroxylated metabolites 5-OH-BDE-47 and 6-OH-BDE-47 stimulate estradiol secretion in the ovary by activating aromatase expression

► For the first time demonstrated the effects of BDE-47 metabolites in the ovary. ► 5-OH-BDE-47 and 6-OH-BDE-47 increased estradiol secretion and the E2/T ratio. ► Both hydroxylated PBDE metabolites increased aromatase gene and protein expression.