کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859644 | 1132496 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
11β-Hydroxysteroid dehydrogenase (11β-HSD) regulates glucocorticoid action by catalyzing the interconversion of active cortisol and inactive cortisone in glucocorticoid and mineralocorticoid target tissues. Two distinct isoforms, 11β-HSD1 and 11β-HSD2, have been characterized. 11β-HSD1 is widely expressed, uses NADP+/NADPH as cofactors, and contributes to the metabolic syndrome and related conditions by increasing cortisol level. 11β-HSD2 is an NAD+-dependent oxidase, converting cortisol to cortisone to lower active glucocorticoid level. The inhibition of 11β-HSD2 activity is generally detrimental to health because the buildup of local cortisol concentration can cause symptoms of apparent mineralocorticoid excess, fetal developmental defect and lower testosterone level in males. In this review, we focus on many environmental inhibitors of 11β-HSD2 including licorice components, gossypol, phthalates, organotins, alkylphenols and perfluorinated substances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 285, Issue 3, 29 July 2011, Pages 83-89
Journal: Toxicology - Volume 285, Issue 3, 29 July 2011, Pages 83-89
نویسندگان
Xue Ma, Qing-Quan Lian, Qiang Dong, Ren-Shan Ge,