Effect of 2,2′,4,4′-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells

- BP2 affects the expression of steroidogenic enzyme genes in Leydig cells.
- BP2 effect on steroidogenic enzyme gene expressions was mediated by TRα.
- BP2 affects the cAMP-induced promoter activity of steroidogenic enzyme genes.
- BP2 affects Nur77-activated promoter activity of steroidogenic enzyme genes.
- BP2 inhibits testicular steroidogenesis in mice.