کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5865600 1136520 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safflower yellow for acute ischemic stroke: A systematic review of randomized controlled trials
ترجمه فارسی عنوان
گلرنگ زرد برای سکته مغزی ایسکمی حاد: بررسی سیستماتیک آزمایشات تصادفی کنترل شده
کلمات کلیدی
گلرنگ زرد، سکته مغزی ایسکمیک حاد بررسی سیستماتیک، متاآنالیز،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
چکیده انگلیسی

SummaryObjectivesStroke is one of the most common causes of mortality worldwide. Safflower yellow is widely used for the treatment of acute ischemic stroke in China. Several trials comparing safflower yellow and placebo or no intervention were unavailable for prior meta-analysis. Here, we present an updated and expanded systematic review, including four new trials, to evaluate the efficacy and safety of safflower yellow for the treatment of acute ischemic stroke.MethodsA comprehensive search was performed in Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, the Allied and Complementary Medicine Database (AMED), China National Knowledge Infrastructure (CNKI), China Biological Medicine Database (CBM), CQVIP Information and Wanfang Database until January 2013. Only randomized controlled trials (RCTs) evaluating the efficacy and safety of safflower yellow for acute ischemic stroke were included. Two researchers (Fan, S.Y. and Lin, N.) independently extracted data, assessed the study quality, and selected trials for inclusion.Results7 RCTs with 762 participants were included. None of the included studies were of high methodological quality. The meta-analysis showed that safflower yellow was more effective assessed by neurological improvement rate [odds ratio (OR), 3.11; 95% confidence interval (CI) 2.06-4.68, P < 0.05] compared with control group. No death was reported in any of the included studies during the follow up period. Only four trials reported adverse events, and skin rash was observed in the treatment group of one trial.ConclusionsSafflower yellow seems to be effective and safe in the treatment of acute ischemic stroke. However, RCTs of high methodological quality are warranted before drawing any conclusion on the efficacy or safety of safflower yellow for acute ischemic stroke.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Complementary Therapies in Medicine - Volume 22, Issue 2, April 2014, Pages 354-361
نویسندگان
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