کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5877495 1566109 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
AJM onlineReviewWarfarin and Vascular Calcification
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
AJM onlineReviewWarfarin and Vascular Calcification
چکیده انگلیسی

The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that ordinarily prevents systemic calcification by scavenging calcium phosphate in the tissues. Warfarin-induced systemic calcification can result in adverse clinical effects. In this review article, we highlight some of the key translational and clinical studies that associate warfarin with vascular calcification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Medicine - Volume 129, Issue 6, June 2016, Pages 635.e1-635.e4
نویسندگان
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