کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5883008 | 1149782 | 2015 | 14 صفحه PDF | دانلود رایگان |
IntroductionSeveral prognostic factors have been identified to predict the outcome of patients with chronic lymphocytic leukemia (CLL), but only a few studies analyzed more markers together.Patients and MethodsTaking advantage of a population of 608 patients, we identified the strongest prognostic markers of survival and, subsequently, in a cohort of 212 patients we integrated data of cytogenetic lesions, IGHV mutational status, and CD38 expression in a new and easy scoring system we called the integrated CLL scoring system (ICSS). ICSS defines 3 groups of risk: (1) low risk (patients with 13qâ or normal fluorescence in-situ hybridization analysis results, mutated IGHV, and CD38) (2) high risk (all 11qâ or 17pâ patients and/or all unmutated IGHV and CD38+ patients); and (3) intermediate risk (all remaining patients).ResultsUsing only these 3 already available prognostic factors, we were able to properly redefine patients and better predict the clinical course of the disease.ConclusionICSS could become a useful tool for CLL patients' management.
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 10, October 2015, Pages 612-620.e5