کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5883046 1149786 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original StudyOverexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Original StudyOverexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia
چکیده انگلیسی

BackgroundThe prognosis of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) is very heterogeneous.Patients and MethodsWe analyzed the prognostic value of several genes in a cohort of 85 MDS and AML patients.ResultsOverexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003 and P < .001, respectively). Furthermore, the higher expression of myelocytomatosis oncogene was associated with a lower response to azacitidine (P = .03).ConclusionIn the current study we identified a specific gene expression profile as prognostic factors for response to azacitidine and survival in MDS and AML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 4, April 2015, Pages 236-244
نویسندگان
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