کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5885135 1567678 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CardiovascularDiastolic dysfunction as a predictor of weaning failure: A systematic review and meta-analysis
ترجمه فارسی عنوان
اختلال عملکرد قلبی-عروقی دیاستولیک به عنوان پیش بینی کننده نارسایی واژگونی: بررسی منظم و متاآنالیز
کلمات کلیدی
شکستگی خوابیده، اختلال عملکرد دیاستولیک، داپلر اکوکاردیوگرافی، متاآنالیز،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

PurposeWeaning failure and prolonged mechanical ventilation are associated with increased morbidity, cost of care, and high mortality rates. In the last few years, cardiac performance has been recognized as a common etiology of weaning failure, and growing evidence suggests that left ventricular diastolic dysfunction is a key factor that determines weaning outcomes. Therefore, we performed a systematic review and a meta-analysis to evaluate whether diastolic dysfunction in the critically ill patient subjected to mechanical ventilation is an independent predictor of weaning failure.Materials and methodsWe searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, LILACS, Google Scholar, and ClinicalTrials.gov from inception to September 2014, along with conferences proceeding from January 2005 through September 2014, and included Observational Studies and Randomized Clinical Trials evaluating predictors of weaning failure.ResultsTen studies were included in the systematic review; and 7, in the meta-analysis (6 observational studies and 1 randomized controlled trial). Patients who developed weaning failure had a higher E/e′ ratio when compared with those who did not (mean difference, 2.65; 95% confidence interval, 0.52-4.79; P= .01); however, there was no difference in the E/A ratio (mean difference, 0.07; 95% confidence interval, − 0.04 to 0.18; P= .22). Both the E/e′ and E/A ratios were associated with weaning-induced pulmonary edema at the end of a spontaneous breathing trial.ConclusionA higher E/e′ ratio is significantly associated with weaning failure, although a high heterogeneity of diastolic dysfunction criteria and different clinical scenarios limit additional conclusions linking diastolic dysfunction with weaning failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Critical Care - Volume 34, August 2016, Pages 135-141
نویسندگان
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