The methodology and pharmacokinetics study of intraventricular administration of vancomycin in patients with intracranial infections after craniotomy

The combined IV and ICV administration may improve CSF vancomycin concentrations without side effects at the same dosage. Our finding suggests that it can be an option for the treatment of severe intracranial infections after craniotomy; however, its safety and effectiveness need to be confirmed by further large-scale studies.