کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5887493 1151730 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The potential therapeutic role of myeloid-derived suppressor cells in autoimmune arthritis
ترجمه فارسی عنوان
نقش بالقوه درمانی سلول های سرکوبگر میلوئیدی در آرتریت اتوایمیون
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

ObjectiveThe aim of this review is to evaluate the roles of myeloid-derived suppressor cells (MDSC) in autoimmune arthritis.MethodsThe terms “myeloid-derived suppressor cells,” “regulatory T cell,” “Th17 cell” and “autoimmune arthritis” were used for literature search from the PubMed. The publications about the characteristics of MDSC, the immunosuppression of MDSC, the role of MDSC in the regulation of Tregs and Th17 cells, and the potential clinical applications of MDSC against rheumatoid arthritis (RA) were identified, retrieved and reviewed.ResultsMDSC are defined as a heterogeneous population of pathologically activated immature and mature myeloid cells consisting of granulocytic and monocytic subsets. Published data showed that the role of MDSC in Tregs and Th17 cells expansion were inconsistent. Given their role in suppressing T-cell responses, MDSC have been tested for their capability of preventing RA.ConclusionsAlthough MDSC hold promise in the treatment of RA, their exact role in the expansion of Tregs and Th17 cells is unclear during RA. The definite effect of MDSC in RA therapy needs to be studied further.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Arthritis and Rheumatism - Volume 45, Issue 4, February 2016, Pages 490-495
نویسندگان
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