miR-106a overexpression and pRB downregulation in sporadic colorectal cancer

► Rb1 LOH showed no correlation with mRNA and protein expression. ► No Rb1 promoter methylation was detected in colorectal tumor and normal tissue. ► Rb1 mRNA was higher in tumors in comparison to normal colonic tissue. ► miR-106a was significantly higher in tumor in comparison to normal colonic tissue. ► Loss of pRb was found in majority of tumors.