Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas

► The FOXF1 protein is detected only in stroma of adjacent normal colorectal mucosa. ► FOXF1 is mislocalized in the epithelial cytoplasm of colorectal adenocarcinomas. ► FOXF1 is undetectable in tumor-associated stroma of most colorectal adenocarcinomas. ► Cytoplasmically mislocalized FOXF1 is associated with the malignancy of colon cancer. ► FOXF1 is a potential predictor for the prognosis of colorectal cancer.