کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5888306 1152309 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma
چکیده انگلیسی

To explore the polymorphisms and mutations of mitochondrial ATPase6 gene in Chinese patients with osteosarcoma and their possible association with carcinogenesis, direct DNA sequencing method was used to detect the variants of the mitochondrial ATPase6 gene in 39 patients with osteosarcoma. We found mutations of the mitochondrial ATPase6 gene in 24/39 (61.5%) of the tested osteosarcoma samples, and identified 27 variant sites in ATPase6 coding regions. We did not detect any new polymorphisms in osteosarcoma, nor was there any association between variants and the three histopathological subtypes. These data demonstrated that mtDNA mutations within the ATPase6 gene are a frequent event in Chinese patients with osteosarcoma.

► Direct DNA sequencing method was used to detect the variants of the mitochondrial ATPase6 gene in 39 Chinese patients with osteosarcoma. ► 24/39 (61.5%) of the tested osteosarcoma samples harbor ATPase6 mutations. ► Twenty-seven variant sites in ATPase6 coding regions were found in Chinese osteosarcoma patients. ► There is no association between variants and the three histopathological subtypes. ► ATPase6 mutations may play a role in the tumorigenesis and development of osteosarcoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 94, Issue 1, February 2013, Pages 285-288
نویسندگان
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