Aberrant expression of the P2 promoter-specific transcript Runx1 in epiphyseal cartilage of Trps1-null mice

► Runx1 was identified as a downstream target gene of Trps1 by a DNA array. ► Runx1 expression was repressed by Trps1 binding to the GATA site of the P2 promoter. ► The aberrant expression of the P2 transcripts was detected in the growth plates of Trps1-null mice.