کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5893891 | 1568394 | 2014 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Levels of brain derived neurotrophic factors across gestation in women with preeclampsia
ترجمه فارسی عنوان
سطوح مغز از عوامل مغناطیسی در طول بارداری در زنان مبتلا به پره اکلامپسی به دست می آید
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کلمات کلیدی
Maternal body mass indexTrkBLMPBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز last menstrual period - آخرین دوره قاعدگیSES - آنdocosahexaenoic acid - اسید داکوزاگزوائونیکPregnancy - بارداریplacental development - توسعه جفتیDHA - دوکوساهگزائنوئیک اسیدBMI - شاخص توده بدنیbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Blood pressure - فشارخونsocioeconomic status - وضعیت اجتماعی و اقتصادیPreeclampsia - پری اکلامپسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Preeclampsia (PE) is a major pregnancy complication of placental origin which leads to adverse pregnancy outcome. Brain derived neurotrophic factor (BDNF) is suggested to promote trophoblast growth and regulate placental and fetal development. This study for the first time examines the levels of maternal plasma BDNF at various time points during gestation, cord plasma and placental BDNF levels and their association with birth outcome in women with PE. Normotensive control (NC) women (n = 89) and women with PE (n = 61) were followed at three different time points [16-20 weeks (T1), 26-30 weeks (T2) and at delivery (T3)]. Maternal blood at all time points and cord blood was collected. Results indicate that maternal BDNF levels at T1 (p = 0.050) and T3 (p = 0.025) were lower in women with PE than in NC women. Cord BDNF levels at delivery in women with PE were lower (p = 0.032) than those in NC women. Placental BDNF gene expression was also lower (p = 0.0082) in women with PE than in NC women. Our data suggests that BDNF plays an important role in the development of the materno-fetal-placental unit during pregnancy. Alteration in the levels of BDNF during pregnancy may be associated with an abnormal development of the placenta resulting in PE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 37, October 2014, Pages 36-40
Journal: International Journal of Developmental Neuroscience - Volume 37, October 2014, Pages 36-40
نویسندگان
Vandita D'Souza, Vidya Patil, Hemlata Pisal, Karuna Randhir, Asmita Joshi, Savita Mehendale, Girija Wagh, Sanjay Gupte, Sadhana Joshi,