کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5894139 1568562 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro
چکیده انگلیسی
Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 46, October 2016, Pages 87-91
نویسندگان
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