کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5896606 | 1568724 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms
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کلمات کلیدی
IL6hs-CRPNF-kBIL-6IL-1IL-8SBPBF% - BF٪inflammation - التهاب( توروم) Interleukin-8 - اینترلوکین -8interleukin-6 - اینترلوکین ۶interleukin-1 - اینترلوکین-1WAT, White adipose tissue - بافت چربی سفید، بافت ادیپوز سفیدtumor necrosis factor alpha - تومور نکروز عامل آلفاbody fat percentage - درصد چربی بدنWaist circumference - دور کمرbody mass index - شاخص توده بدنBMI - شاخص توده بدنیTNF-α - فاکتور نکروز توموری آلفاsystolic blood pressure - فشار خون سیستولیکObesity - مرض چاقیprevalence ratio - نسبت شیوعC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Polymorphisms - پلی مورفیسمSNP - چندریختی تک-نوکلئوتیدWAT - چی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Overweight and obesity are associated with chronic and subclinical inflammation due to an imbalance of inflammatory mediators. However, the association with gene polymorphism has been rarely studied in children. The aim of this study was to determine if serum concentrations of C-reactive protein (CRP) and interleukin-6 (IL-6) are related to the IL6 rs1800795, IL6 rs2069845 and CRP rs1205 polymorphisms (SNPs) according to body mass index (BMI) in a sample of children and adolescents. A cross-sectional study in 470 students between 7 and 17 years of age of anthropometric characteristics, high sensitivity-CRP (Hs-CRP) and IL-6 levels and three SNPs genotyped. The prevalence ratio of hs-CRP > 3 mg/L in obese individuals was 4.15 (CI 2.43-7.06; p = 0.01), and it was 1.91 (CI 1.03-3.55; p = 0.03) in overweight individuals and 1.74 (CI 1.05-2.88 p = 0.03) in females. Individuals with waist circumference (WC) and body fat percentage (BF%) alterations showed elevated levels of hs-CRP (p = 4.3 Ã 10â5 and p = 5.3 Ã 10â6). The combination of any two anthropometric measurement increases CRP levels, especially combinations with obesity body mass index (BMI): BMI + WC and BMI + BF%. Among the overweight/obesity group, T allele carriers of CRP rs1205 showed lower levels of hs-CRP (0.5, IQR = 0.3-1.8 mg/L) than CC homozygotes (1.5, IQR = 0.4-3.4 mg/L, p = 0.018). Additionally, considering subjects with two or three anthropometric alterations for CRP rs1205: rs1205 T allele carriers had lower levels of hs-CRP (0.7, IQR = 0.3-2.7 mg/L) than CC homozygotes (1.2, IQR = 0.5-3.5 mg/L, p = 0.02). In conclusion, carriers of the rs1205/T allele with higher BMIs had lower levels of hs-CRP. Schoolchildren who were overweight/obese had higher levels of CRP and IL-6, whereas individuals with WC and BF% alterations had higher levels of CRP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 88, December 2016, Pages 177-183
Journal: Cytokine - Volume 88, December 2016, Pages 177-183
نویسندگان
P.F. Todendi, L.G. Possuelo, E.I. Klinger, C.P. Reuter, M.S. Burgos, D.J. Moura, M. Fiegenbaum, Andréia Rosane de Moura Valim,