کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5896882 | 1155245 | 2015 | 4 صفحه PDF | دانلود رایگان |

- The rs8048002 polymorphism is associated with risk of developing ACS.
- The individual with the C allele had a 4.55-fold increased the risk of developing ACS.
- The TCÂ +Â CC genotypes were significantly associated with increased risk of ACS (ORÂ =Â 4.56, pCÂ =Â 0.004).
Recently, an intronic single nucleotide polymorphism (rs8048002) in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to several inflammatory diseases. The aim of the present study was to test for an association between this MHC2TA gene polymorphism and susceptibility to the risk of developing acute coronary syndromes (ACS) in a group of Mexicans patients. The single nucleotide polymorphism (rs8048002) of the MHC2TA gene was analyzed by 5â² exonuclease TaqMan genotyping assays in a group of 452 patients with ACS and 456 healthy controls. The C allele and TC genotype were associated with risk of developing ACS (ORÂ =Â 4.55, pCÂ =Â 6Â ÃÂ 10â4 and ORÂ =Â 4.41, pCÂ =Â 1.5Â ÃÂ 10â3, respectively). Multiple logistic analysis was used for estimate risk between ACS patients and controls adjusted by cardiovascular risk factors (gender, age, hypertension, dyslipidemia, smoking, diabetes, body mass index and alcohol consumption). In this analysis, the TCÂ +Â CC genotypes were significantly associated with increased risk of ACS as compared to TT genotype (ORÂ =Â 4.56, pCÂ =Â 0.004).In summary, our data suggest that the MHC2TA rs8048002 CÂ >Â T gene polymorphism plays an important role in the risk of developing ACS.
Journal: Cytokine - Volume 71, Issue 2, February 2015, Pages 268-271