کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5896966 1155249 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of IL-17 in atherosclerosis and related autoimmunity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Regulation of IL-17 in atherosclerosis and related autoimmunity
چکیده انگلیسی

Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 74, Issue 2, August 2015, Pages 219-227
نویسندگان
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