IL-15 activated human peripheral blood dendritic cell kill allogeneic and xenogeneic endothelial cells via apoptosis

► Human dendritic cell directly interact and adhere to endothelial cells. ► IL-15 activated dendritic cell kill endothelial cells via caspase activation. ► IL-15 activated dendritic cell is crucial for survival of graft in transplantation. ► IL-15 represents an important regulatory cytokine in transplant.