A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion

► A short course of H2S infusion reduces lung and kidney injury in endotoxemia. ► Prolonged H2S infusion does not enhance organ protective effects. ► H2S infusion exaggerated systemic pro-inflammatory response during endotoxemia. ► In whole blood stimulation, H2S had solely anti-inflammatory effects. ► Which were abrogated by co-incubation with neutralizing anti-IL10 antibody.