Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: A clinic-based case-control study

► Of 30 cytokines analyzed, sIL-2R was most strongly associated with FL and DLBCL. ► IL1RA and IL-12 were also strongly associated with both subtypes. ► HGF, MIG, and MIP-1α had stronger associations with DLBCL than with FL. ► Associations with IL-6, IL-8, IL-10, IFN-γ, IP-10 and VEGF were specific to DLBCL. ► IL-1RA, sIL-2R, MIG, IP-10, IL-8 and IL-12 best explained case-control differences.