کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5897371 | 1155269 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LPLSDSSIELsIBDTCMPLNIL-21MLNTem - این استInflammatory bowel disease - بیماریهای التهابی رودهcentral memory T cells - سلول های T حافظه مرکزیeffector memory T cells - سلول های حافظه اثر گذار TDextran sulfate sodium - سولفات سدیم دکسترانlamina propria lymphocytes - لنفاوی لامپ پروپریاintraepithelial lymphocytes - لنفوسیت های داخل اپیتلیالDSS-induced colitis - کولیت ناشی از DSSPeripheral Lymph Node - گره لنفاوی محیطیmesenteric lymph node - گره لنفاوی مزانتریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a novel IL-21 isoform named IL-21iso. In this study, we found that in addition to the conventional IL-21, IL-21iso mRNA was also expressed in the colon with DSS-induced colitis. To investigate whether IL-21iso plays a role in DSS-induced colitis, we established transgenic mice (mIL-21iso-Tg mice) that expressed mouse IL-21iso under the control of the lck proximal promoter. Although mIL-21iso-Tg mice did not have any gross physical abnormalities, their peripheral lymphocytes counts were higher than those in wild-type littermates. Notably, their CD8+ T cell and CD4+ effector memory T-cell populations were elevated. DSS-induced colitis was far more severe in the mIL-21iso-Tg mice than in wild-type mice, and was accompanied by a marked loss of body weight and by colon inflammation with increased cellular infiltration. In DSS-treated mice, colon tissues from mIL-21iso-Tg mice had significantly higher gene activation levels for cytokines such as IL-17A, TNF-α, IL-6, IL-10, and IL-4, and for transcription factors such as T-bet, GATA-3, RORγt, and Foxp3, than were found in wild-type mice. These results indicate that besides IL-21, IL-21iso may be another regulator of gut inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 62, Issue 2, May 2013, Pages 262-271
Journal: Cytokine - Volume 62, Issue 2, May 2013, Pages 262-271
نویسندگان
Akemi Araki, Hidetoshi Nara, Mizanur Rahman, Tadashi Onoda, Jun Li, Farha Matin Juliana, Lianjin Jin, Kazuko Murata, Yuji Takeda, Hironobu Asao,