Keywords: SLE; IL-21; Single nucleotide polymorphism; T allele; Genotypes;
مقالات ISI (ترجمه نشده)
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Keywords: IL-2; IL-15; IL-21; natural killer cells
Circulating CXCR5+CD4+ T cells participate in the IgE accumulation in allergic asthma
Keywords: Follicular helper T; CXCR5; Allergic asthma; IL-21; IL-4;
Increased costimulatory molecule expression of thymic and peripheral B cells and a sensitivity to IL-21 in myasthenia gravis
Keywords: Myasthenia gravis; B cells; Thymus; IL-21; Co-stimulation;
IL-21 alleviates allergic asthma in DOCK8-knockout mice
Keywords: DOCK8 gene; Allergic asthma; Ovalbumin; Murine model; IL-21; rmIL-21; recombinant mouse interleukin-21; DOCK8; dedicator of cytokinesis 8; STAT3; signal transducer and activator of transcription 3; TYK2; tyrosine kinase 2; DIDS; DOCK8 immunodeficiency syn
Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-21
Keywords: Anaphylaxis; Eotaxin receptor; Duodenum; IL-21; Neutrophil; IL-21iso; IL-21 isoform; Tg; transgenic; WT; wild type;
A new approach to CAR T-cell gene engineering and cultivation using piggyBac transposon in the presence of IL-4, IL-7 and IL-21
Keywords: CAR T cells; cancer immunotherapy; IL-4; IL-7; IL-21; piggyBac transposon;
IL-21 dependent Granzyme B production of B-cells is decreased in patients with lupus nephritis
Keywords: SLE; IL-21; Granzyme B; Lupus nephritis;
Follicular helper T cells promote the effector functions of CD8+ T cells via the provision of IL-21, which is downregulated due to PD-1/PD-L1-mediated suppression in colorectal cancer
Keywords: CD8; Colorectal cancer; CXCR5; IL-21; Tfh cell;
Th9 cells promote antitumor immunity via IL-9 and IL-21 and demonstrate atypical cytokine expression in breast cancer
Keywords: Th9 cell; Breast cancer; IL-9; IL-21;
Association of polymorphisms in key Th-17 immune response genes with HBeAg-positive chronic hepatitis B susceptibility and response to PEG-IFNa-2α
Keywords: Chronic hepatitis B; IL-17; IL-21; IL-23R; SNP; Efficacy;
Original articleImmune characteristics study of AG490, a signal pathway inhibitor, in EAE model mice
Keywords: Tfh; EAE; IL-21; AG490; Model mice;
CD4+IL-21+T cells are correlated with regulatory T cells and IL-21 promotes regulatory T cells survival during HIV infection
Keywords: HIV; IL-21; Regulatory T cell;
Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes
Keywords: Type 1 diabetes; Immunotherapy; Combination therapy; IL-21; GLP-1; Mouse models;
IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo
Keywords: IL-10; interleukin 10; IL-21; interleukin 21; CD40L; cluster of differentiation 40 ligand; Tim1; T-cell immunoglobulin and mucin domain 1; RANKL; receptor activator of nuclear factor kappa-B ligand; Periodontitis; B10; IL-21; Anti-Tim1; IL-10;
Human regulatory B cells control the TFH cell response
Keywords: Regulatory B cells; follicular T helper cells; IL-12; IL-21; antibody production; humoral immune response; Bcl-6; B-cell lymphoma 6; Breg; Regulatory B; DC; Dendritic cell; Foxp3; Forkhead box P3; GC; Germinal center; ICAM; Intercellular adhesion molecule
TGF-β and IL-21 cooperatively stimulate activated CD8+ T cells to differentiate into Tc17 cells
Keywords: IL-6; IL-21; Tc1; Tc17; T cell plasticity; TGF-β
A higher frequency of CD4+Â CXCR5+ T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis
Keywords: TFH cell; Henoch-Schönlein purpura nephritis; IL-21; eGFR; IL-4;
The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus
Keywords: Bcl-6; cTfh; SLE; Disease activity; IL-21; TET2;
Differences in frequency and regulation of T follicular helper cells between newly diagnosed and chronic pediatric immune thrombocytopenia
Keywords: T follicular helper cell; ICOSL; IL-21; BAFF; TACI; ITP;
Interleukin-21 administration leads to enhanced antigen-specific T cell responses and natural killer cells in HIV-1 vaccinated mice
Keywords: HIV-1 vaccine; Immune responses; Multifunction; Cytokine adjuvant; IL-21;
A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
Keywords: IL-21; BATF; STAT3; IRF4; Blimp-1; CD8 T cell; LCMV
The role of IL-21 in immunity and cancer
Keywords: IL-21; Immune response; Cancer;
Mechanisms of allergy and clinical immunologyHuman B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of TH1/TFH signatures
Keywords: B cell; T-cell plasticity; IL-21; IFN-γ; coexpression; T-bet; Bcl-6; antibody response; crosstalk; Bcl-6; B cell lymphoma 6; DC; Dendritic cell; DP; Double positive; ICOS; Inducible costimulator; LN; Lymph node; PD-1; Programmed cell death 1; PE; Phycoer
Research ArticleCD4+CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses
Keywords: HCV; hepatitis C virus; LCMV; lymphocytic choriomeningitis virus; TFH; T follicular helper; PBMC; peripheral blood mononuclear cells; Chronic hepatitis C; Immunology; T follicular helper cells; IL-21; Intra-hepatic;
Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis
Keywords: Chronic periodontitis; IFN-γ; IL-17; IL-21; IL-22; Saliva;
Early exposure to interleukin-21 limits rapidly generated anti–Epstein-Barr virus T-cell line differentiation
Keywords: adoptive immunotherapy; CD27; Epstein-Barr virus; IL-21; T cell; T-cell memory
Multiple effects of IL-21 on human NK cells in ex vivo expansion
Keywords: Natural killer (NK) cells; Ex vivo expansion; IL-21; Apoptosis; Cell cycle;
Interleukin (IL)-21 promoter polymorphism increases the risk of thyroid cancer in Chinese population
Keywords: CI; confidence interval; MAF; minor allele frequency; OR; odds ratio; SNP; single nucleotide polymorphism; Thyroid cancer; IL-21; Polymorphisms;
Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgDâCD27â) in the elderly
Keywords: B lymphocytes; Chemokine receptors; Inflamm-aging; Elderly; IL-21; Granzyme B;
Frequency of CD4+CXCR5+ TFH cells in patients with hepatitis b virus-associated membranous nephropathy
Keywords: TFH cell; HBV-MN; IL-21; IL-4
Th17 cells and related cytokines in unexplained recurrent spontaneous miscarriage at the implantation window
Keywords: IL-17; IL-21; IL-23; IL-6; TGF-β; unexplained recurrent spontaneous miscarriage;
Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjögren's syndrome
Keywords: Sjögren's syndrome; Epithelial cells; Germinal centers; Follicular helper T cells; IL-21;
Expansion of NK cells by engineered K562 cells co-expressing 4-1BBL and mMICA, combined with soluble IL-21
Keywords: NK cell; natural killer cell; 4-1BBL; 4-1BB ligand; mMICA; membrane-bound MHC class I chain-related protein A; sIL-21; soluble interleukin 21; PBMCs; peripheral blood mononuclear cells; sMICA; soluble MICA; ADCC; Ab-depend cell cytotoxicity; TNF; tumor ne
The IL-2 cytokine family in cancer immunotherapy
Keywords: Cytokine; IL-2; IL-15; IL-21; Lymphocyte; T-cell; NK cell; Cancer; Immunotherapy;
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency
Keywords: IL-21; early-onset inflammatory bowel disease; common variable immunodeficiency; exome sequencing; APC; Allophycocyanin; CD40L; CD40 ligand; CVID; Common variable immunodeficiency; DMEM; Dulbecco modified Eagle medium; IBD; Inflammatory bowel disease; IL-
Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis
Keywords: DSS; dextran sulfate sodium; IBD; inflammatory bowel disease; IELs; intraepithelial lymphocytes; LPLs; lamina propria lymphocytes; mLN; mesenteric lymph node; pLN; peripheral lymph node; TCM; central memory T cells; TEM; effector memory T cells; IL-21; IL
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function
Keywords: Autosomal dominant hyper-IgE syndrome; STAT3; STAT1; IL-21; human CD8+ T cells; memory; differentiation; AD-HIES; Autosomal dominant hyper-IgE syndrome; BCL; B-cell lymphoma; CTV; CellTrace Violet; EOMES; Eomesodermin; IL-21R; IL-21 receptor; LCMV; Lympho
Efficient production of recombinant IL-21 proteins for pre-clinical studies by a two-step dilution refolding method
Keywords: IL-21; Expression; Refolding; Bioactivity
IL-21-producer CD4+ T cell kinetics during primary simian immunodeficiency virus infection
Keywords: HIV; SIV; IL-21; B-cells; Th1
Effect of IL-15 on IgG versus IgE antibody-secreting cells in vitro
Keywords: ELISPOT; IL-15; IL-21; IgE; IgG;
Chicken interleukin-21 is costimulatory for T cells and blocks maturation of dendritic cells
Keywords: Chicken; Cytokines; IL-21; Dendritic cell
Interleukin-21 in hemodialyzed patients: Association with the etiology of chronic kidney disease and the seropositivity against hepatitis C virus infection
Keywords: Anti-HCV seropositivity; Glomerulonephritis; Hemodialysis; IL-21
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice
Keywords: Type 1 diabetes; IL-21; IL-17; Signaling pathways
Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse
Keywords: IL-17-secreting CD8+T cells; IL-17; IL-21; Multiple sclerosis; Neuromyelitis optica; Th17 cells
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling
Keywords: Bid; BH3 interacting domain death agonist; CA14; carbonic anhydrase XIV; CASP8; caspase-8; ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; IL-21; interleukin-21; IL21R; interleukin-21 receptor; IL2RG; interleukin 2 receptor, gamma; NCtag
Follicular helper T cells poise immune responses to the development of autoimmune pathology
Keywords: Follicular helper T cells; Tolerance; Systemic lupus erythematosus; ICOS; BCL-6; IL-21
Interleukin-21 and rituximab enhance NK cell functionality in patients with B-cell chronic lymphocytic leukaemia
Keywords: B-cell chronic lymphocytic leukaemia; NK cells; IL-21; Rituximab; Immunotherapy; Cancer immunology;
The role of IL-21 in hematological malignancies
Keywords: IL-21; interleukin-21; rIL-21; recombinant IL-21; IL-21R; IL-21 receptor; JAK/STAT; Janus-activated kinase/signal transducer and activator of transcription; CpG; cytosine-phosphate-guanosine; ODN; oligodeoxynucleotide; anti-BCR; anti-B-cell-receptor antib
Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells
Keywords: IL-21; CD8 T lymphocytes; Cytotoxicity; HIV; Immunotherapy