Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly

Our data demonstrate that in the elderly, naïve/memory B cell populations present a different expression of the studied receptors that could be discussed in terms of “inflamm-aging”. In particular IgG+IgD−CD27− DN B cells show a tissue trafficking phenotype and they can be stimulated to produce GrB.