کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5555256 | 1559738 | 2017 | 5 صفحه PDF | دانلود رایگان |

- Breast cancer patients presented higher levels of IL-9 expression.
- IL-9-expressing Th9 cells were enriched in the CCR4â CCR6â CXCR3â subset.
- Th9 cells presented elevated IL-10 and IL-21 expression upon TCR stimulation.
- Th9 cells mediated better cytotoxicity in CD8+ T cells.
- Tumor-infiltrating Th9 cells demonstrated higher IL-21 and lower IL-10 levels.
Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8+ T cells and immunomodulatory roles mediated by CD4+ T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. In this study, we found that IL-9 expression in the serum and in circulating CD4+ T cells were significantly upregulated in breast cancer patients compared to healthy controls. The IL-9-expressing Th9 cells were enriched in the CCR4â CCR6â CXCR3â subset. Upon TCR stimulation, this subset also presented potent IL-10 and IL-21 expression in addition to IL-9 expression. CCR4â CCR6â CXCR3â CD4+ T cells also assisted in the killing of autologous tumor cells by CD8+ T cells, but did not initiate cytotoxicity by themselves. This enhancement in CD8+ T cell-mediated cytotoxicity was dependent on IL-9 as well as on IL-21. Interestingly, the tumor-infiltrating Th9 cells presented comparable IL-9, reduced IL-10, and elevated IL-21 expression compared with their counterparts in the peripheral blood. Together, these results demonstrated that IL-9-expressing Th9 cells were upregulated in breast cancer patients and potentially possessed antitumor roles by enhancing CD8+ T cell-mediated cytotoxicity.
Journal: International Immunopharmacology - Volume 52, November 2017, Pages 163-167