Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients

► TGF-β1-509 TT genotype frequencies were significantly increased in cirrhotic and HCC groups. ► TNF-α-308 AA genotype frequencies were significantly increased in cirrhotic and HCC groups. ► Serum TGF-β1 was significantly increased in TGF-β1-509 TT. ► Serum TNF-α level was significantly increased in TNF-α-308 AA genotypes.