Alteration of intracellular secretory acute phase response proteins expressed in human hepatocyte induced by exposure with interleukin-6

► We adopted the FD-LC-MS/MS method to reveal proteomics response to IL-6. ► The temporal altered expressions of intracellular acute phase proteins were observed. ► Nine altered sAPR proteins were identified in the cells in response to IL-6. ► A mechanism for protein synthesis among the acute phase proteins might be different. ► The transmission of transferrin might be faster than the other acute phase proteins.