کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5898107 | 1155288 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chemotactic cytokine receptor 5 gene polymorphism: Relevance to microvascular complications in type 2 diabetes Chemotactic cytokine receptor 5 gene polymorphism: Relevance to microvascular complications in type 2 diabetes](/preview/png/5898107.png)
We investigated the involvement of chemotactic cytokine receptor 5 (CCR5) gene polymorphism in microvascular complications of T2DM. All subjects were genotyped with the 59029 SNP in the CCR5 gene. The genotype/allele frequencies did not differ between T2DM patients and controls. Genotype distribution was compared in patients with and without complications (nephropathy, retinopathy and neuropathy). The frequency of A allele was significantly higher in patients with complications (OR for A allele 3.07, 95% CI 2.49-3.77). The A allele carriage was associated with diabetic nephropathy (OR 6.17, 95% CI 3.28-11.6). An association was observed between 59029 polymorphism and age at T2DM onset. The A allele was more frequent in early onset than in late onset patients. For AA homozygotes OR was 2.38 (1.19-4.76) and 2.26 (1.12-4.58) in complicated and uncomplicated subgroups, respectively. These results suggest that CCR5 gene polymorphism is associated with diabetic nephropathy in T2DM.
⺠We investigated CCR5 gene polymorphism in type 2 diabetes and its complications. ⺠CCR5 59029 SNP is associated with T2DM complications, mainly diabetic nephropathy. ⺠We observed an association of the A allele carriage with early onset of T2DM.
Journal: Cytokine - Volume 58, Issue 2, May 2012, Pages 213-217