Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells

► Seven splice isoforms of cytokine mda-7/IL-24 were characterized. ► The shortest isoform, lacking three exons induced more apoptosis in U2OS cancer cells than did the full-length isoform. ► However, this short isoform displayed no effect on the viability of non-transformed NOK cells.