Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women

► Tumour necrosis factor alpha involved in the pathogenesis of metabolic syndrome. ► Impact of the G-308A TNF-α variant on components of the metabolic syndrome. ► TNF-α mutant allele associated with most of the metabolic risk factors. ► TNFα gene associated with components of metabolic syndrome. ► TNFα gene is not associated with Insulin resistance and hyperglycemia.