Differences in the concentration and correlation of cervical immune markers among HPV positive and negative perimenopausal women

► Cervical immune markers among HPV negative and positive perimenopausal women. ► HPV +ve have higher [C] of IL-5, IL-9, IL-13, IL-17, EOTAXIN, GM-CSF, and MIP-1α. ► T-cell and pro-inflammatory cytokines correlate with IL-2 in HPV −ve women. ► These same markers correlate with EOTAXIN in HPV +ve women. ► Shifts in local immune phenotypes may explain HPV natural history in older women.