Antibodies against Helicobacter pylori heat shock protein 60 aggravate HSP60-mediated proinflammatory responses

► We examine the role of anti-HpHSP60 antibody in host immune responses. ► Anti-HpHSP60 polyclonal sera of Helicobacter pylori - infected patients enhance HpHSP60-mediated IL-8 and TNF-α secretion. ► The pathogen-specific antibodies may execute potential immune functions.