کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5901122 1568900 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genes encoding aromatases in teleosts: Evolution and expression regulation
ترجمه فارسی عنوان
ژن هایی که آروماتاز ​​را در تلوزیون ها رمزگذاری می کنند: مقررات تکامل و بیان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Cytochrome P450 aromatases, encoded by cyp19a1 genes, catalyzes the conversion of androgens to estrogens and plays important roles in the reproduction of vertebrates. Vertebrate cyp19a1 genes showed high synteny in chromosomal locations and conservation in sequences during evolution. However, amphioxus cyp19a1 does not show synteny to vertebrate cyp19a1. Teleost fish possess two copies of the cyp19a1 gene, which were postulated to result from a fish-specific genome duplication. The duplicated copies of fish cyp19a1 genes evolved into the brain and ovarian forms of cytochrome P450 aromatase genes, cyp19a1a and cyp19a1b, respectively, with different regulatory mechanisms of expression, through subfunctionalization under long-term selective pressure. In addition to the estradiol (E2) auto-regulatory loop, there may be other mechanisms responsible for the high expression of aromatase in the teleost brain. The study of the two cyp19a1 copies in teleost fish will shed light on the general evolution, function, and regulation of vertebrate cyp19a1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 205, 1 September 2014, Pages 151-158
نویسندگان
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