Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors

► This review explores the role of the MRAPs in the function of the MCRs. ► Review provides a summary of the melanocortin system and the MRAP discovery. ► Next, it affords the interaction of the MC2R and the different MRAPs. ► Finally, attention is to the interaction of MRAPs with the other MCRs.