کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5901899 1569000 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population
ترجمه فارسی عنوان
سطوح سرمی کپپتین با دیابت نوع 2 و عوارض دیابت در جمعیت چینی همراه است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

PurposeThe aim of this study was to investigate copeptin levels in serum, and assess their associations with type 2 diabetes (T2DM) and diabetic complications.MethodsIn this post hoc analysis, serum levels of copeptin were tested in 306 patients with T2DM. Clinical information including diabetic retinopathy (DR) and diabetic nephropathy (DN) were collected. The relation of serum copeptin with DR and DN were investigated with the use of logistic regression models according to equal quartiles of the distributions of serum copeptin.ResultsWe found that serum copeptin levels were significantly higher in diabetes as compared to normal controls [9.4(IQR, 7.4-12.5) pmol/L vs. 4.1(IQR, 2.5-6.2) pmol/L; P < 0.0001]. In multivariate analysis, there was an increased risk of T2DM associated with copeptin levels (OR 1.312, 95% CI: 1.204-1.403; P < 0.0001) after adjusting for possible confounders. After adjustment for possible confounders, serum copeptin levels were positively associated with the DR (odds ratio [OR], 1.117; 95% confidence interval [CI], 1.072-1.241; P < 0.001) and DN (OR, 1.259; 95% CI, 1.198-1.323; P < 0.001). Compared with the first quartile of serum copeptin levels, the ORs for DR and DN were as follows: second quartile, 1.19 (95% CI, 0.94-1.51, P = 0.12) and 1.37 (95% CI, 0.78-2.37, P = 0.28); third quartile, 1.61 (95% CI, 1.18-2.43, P = 0.005) and 2.12 (95% CI, 1.32-3.27, P = 0.003); fourth quartile, 2.83 (95% CI, 2.04-4.93; P < 0.001) and 3.48 (95% CI, 1.77-7.03; P < 0.001), respectively.ConclusionsUsing a post-hoc analysis our data show that elevated serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population, suggesting a potential role of the AVP system (copeptin) in the pathophysiology of diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 30, Issue 8, November–December 2016, Pages 1566-1570
نویسندگان
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