کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5902423 1156851 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic and epigenetic alterations in Toll like receptor 2 and wound healing impairment in type 2 diabetes patients
ترجمه فارسی عنوان
تغییرات ژنتیکی و اپیگنیک در بیماران مبتلا به دیابت نوع 2 مانند گیرنده 2 و نقص در بهبود زخم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimPersistent hyperglycemic microenvironment in type 2 diabetes mellitus (T2DM) leads to the development of secondary complications like wound healing impairment. Proper co-ordination of innate immune system plays an integral role in wound healing. Toll like receptors (TLRs) are prominent contributors for the induction of the innate immune and inflammation response. TLR2 is an important extracellular member in mammalian TLR family and has been shown to be a potent player in the wound healing mechanism.MethodsExpressional status of TLR2 was seen in wounds of T2DM cases with respect to the severity of wounds in 110 human lower extremity wounds. The methylation status of TLR2 promoter was also examined.ResultsAlthough TLR2 transcripts were downregulated in T2DM wounds compared to control, their levels tend to increase with the severity of T2DM wounds. The methylation status of TLR2 gene promoter was not significantly different among different grades of wounds in T2DM subjects. The CpG sites investigated were totally or partially methylated in majority of DFU cases.ConclusionTLR2 down regulation in wounds of T2DM patients compared to non diabetic patients may lead to development of non healing chronic ulcers in them.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 29, Issue 2, March 2015, Pages 222-229
نویسندگان
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